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Eagles-Chiefs Week 2 Predictions, Spreads, Best Prop Bets

September 10, 2025 by Last Word On Pro Football

The Super Bowl rematch is here, and it’s time to make some money on predictions. While this probably won’t be the same one-sided affair from February, have the Chiefs done enough to take down the reigning Super Bowl champions with the support of the Arrowhead faithful?

Eagles-Chiefs Week 2 Predictions, Spreads, Best Prop Bets

Chiefs vs Eagles (-1.5)
Over/Under: 45.5

Patrick Mahomes is a home underdog for the first time in his career. While this contest will likely be considerably closer than the Super Bowl and anything can happen on any given Sunday, the Eagles still have the superior roster. Loaded with talent at just about every position, the team moved the ball at will against the Dallas Cowboys. While Philadelphia struggled to stop Dak Prescott’s passing attack in Week 1, they may have more luck against Kansas City.

Patrick Mahomes is better than Dak Prescott, but an offense is more than their quarterback. Dallas and Kansas City both have questions along the offensive line, but the Cowboys’ pass-catchers are considerably better than whatever the Chiefs will send out in Week 2. Xavier Worthy may or may not play, and the rest of the depth chart leaves a lot to be desired. With Travis Kelce continuing to look old, Mahomes won’t have many reliable targets to help take down this talented secondary.

Kansas City’s defense did a decent job of shutting down the run in Week 1, but it couldn’t do anything to stop Justin Herbert through the air. Philadelphia has a considerably stronger rushing attack, and its passing attack can be just as dangerous, especially if A.J. Brown and DeVonta Smith play a larger role in the gameplan. Mahomes is a better quarterback than Jalen Hurts, but everything else in this matchup favors the Eagles.

Eagles-Chiefs Predictions: Eagles win, cover spread
UNDER 45.5 points

Best Prop Bets

Patrick Mahomes: UNDER 254.5 Passing Yards

As mentioned above, Patrick Mahomes does not have the best supporting cast entering Week 2. The quarterback barely reached this mark in Week 1’s matchup against the Los Angeles Chargers (258) and now he faces a much better defense and an opposing offense that focuses more on ball control than the high-powered precision of the Chargers. Mahomes will have fewer opportunities to throw the ball and doesn’t have the weapons to lead a highly efficient passing attack.

A.J. Brown: OVER 54.5 Receiving Yards

The squeaky wheel gets the oil. A.J. Brown was one of the Week 1’s biggest disappointments, hauling in just one reception for eight yards on one target. Brown has never shied away from voicing his displeasure when not involved in the offense, and Philadelphia usually gives him the targets to keep him happy. Look for the disgruntled wide receiver to be a featured part of this passing attack and easily eclipse the 54.5-yard mark as the team puts to bed all worries about his usage.

Marquise Brown: UNDER 57.5 Receiving Yards

Marquise Brown became the Chiefs top receiver by default after Xavier Worthy suffered an injury early in Week 1. Left as effectively the only man standing, the veteran finished the night with 10 receptions for 99 yards on 16 targets. On the one hand, receiving this type of volume means Mahomes trusts him. On the other hand, 6.2 yards per target is not a good thing. Brown’s workload should go down now that head coach Andy Reid has a full week to prepare for his current depth chart, and Brown is better in a depth role at his stage in his career.

Main Photo: Mark J. Rebilas – Imagn Images

The post Eagles-Chiefs Week 2 Predictions, Spreads, Best Prop Bets appeared first on Last Word on Pro Football.

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